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KMID : 0903520070500030224
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2007 Volume.50 No. 3 p.224 ~ p.227
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Development of Biologically Active Compounds from Edible Plant Sources-XIX. Isolation of Inhibitory Compound on LDL-Oxidation from the Aerial Parts of Sajabalssuk (Artemisia princeps PAMPANINI, Sajabalssuk)
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Bang Myun-Ho
Song Myoung-Chong
Han Min-Woo
Lee Dae-Young
Cho Jin-Gyeong
Cheng Hae-Gon
Jeong Tae-Sook
Lee Kyung-Tae
Choi Myoung-Sook
Baek Nam-In
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Abstract
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Sajabalssuk (Artemisia princeps PAMPANINI) was extracted with 80% aqueous MeOH, and the concentrated extract was partitioned with EtOAc, n-BuOH and H2O, successively. From the EtOAc fraction, two phenylpropanoids were isolated through the repeated silica gel and ODS column chromatographies. From the results of physico-chemical data including NMR, MS and IR, the chemical structures of the phenylpropanoids were determined as eugenol (1) and (-)-sesamin (2). They were the first to be isolated from Sajabalssuk (Artemisia princeps PAMPANINI, Sajabalssuk). Also, eugenol inhibited LDL-oxidation with the inhibitory activity of 87.8 ± 1.0% at a concentration of 40 μg/ml.
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KEYWORD
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Artemisia princeps PAMPANINI, eugenol, (-)-sesamin, LDL-oxidation
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